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Intron retention generates a novel isoform of the murine vitamin D receptor that acts in a dominant negative way on the vitamin D signaling pathway.

We identified and characterized a novel rat vitamin D receptor isoform (rVDR1), which retains intron 8 of the canonical VDR (rVDR0) during alternative splicing. In this isoform protein directed by the stop codon in this newly identified exon, a part of the ligand binding domain (86 amino acids) is t...

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Sparad:
I publikationen:Mol Cell Biol
Huvudupphov: Ebihara, K, Masuhiro, Y, Kitamoto, T, Suzawa, M, Uematsu, Y, Yoshizawa, T, Ono, T, Harada, H, Matsuda, K, Hasegawa, T, Masushige, S, Kato, S
Materialtyp: Artigo
Språk:Inglês
Utgiven: Taylor & Francis 1996
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC231333/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8668154/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.16.7.3393
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