Intron retention as a productive mechanism in human MAPT: RNA species generated by retention of intron 3Research in context

Summary: Background: Tau is a microtubule-binding protein encoded by the MAPT gene. Tau is essential for several physiological functions and associated with pathological processes, including Alzheimer's disease (AD). Six tau isoforms are typically described in the central nervous system, but curren...

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Bibliografische Detailangaben

Hauptverfasser:	Daniel Ruiz-Gabarre, Laura Vallés-Saiz, Almudena Carnero-Espejo, Isidro Ferrer, Félix Hernández, Ramon Garcia-Escudero, Jesús Ávila, Vega García-Escudero
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2024-02-01
Schriftenreihe:	EBioMedicine
Schlagworte:	Tau Alzheimer's disease Alternative splicing Intron retention Tau isoforms Tauopathies
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2352396423005194
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