Insulin signalling and insulin actions in the muscles and livers of insulin-resistant, insulin receptor substrate 1-deficient mice.

We and others recently generated mice with a targeted disruption of the insulin receptor substrate 1 (IRS-1) gene and demonstrated that they exhibited growth retardation and had resistance to the glucose-lowering effect of insulin. Insulin initiates its biological effects by activating at least two...

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Hlavní autoři: Yamauchi, T, Tobe, K, Tamemoto, H, Ueki, K, Kaburagi, Y, Yamamoto-Honda, R, Takahashi, Y, Yoshizawa, F, Aizawa, S, Akanuma, Y, Sonenberg, N, Yazaki, Y, Kadowaki, T
Médium: Artigo
Jazyk:Inglês
Vydáno: 1996
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC231302/
https://ncbi.nlm.nih.gov/pubmed/8649419
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