Insulin signalling and insulin actions in the muscles and livers of insulin-resistant, insulin receptor substrate 1-deficient mice.

We and others recently generated mice with a targeted disruption of the insulin receptor substrate 1 (IRS-1) gene and demonstrated that they exhibited growth retardation and had resistance to the glucose-lowering effect of insulin. Insulin initiates its biological effects by activating at least two...

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Veröffentlicht in:	Mol Cell Biol
Hauptverfasser:	Yamauchi, T, Tobe, K, Tamemoto, H, Ueki, K, Kaburagi, Y, Yamamoto-Honda, R, Takahashi, Y, Yoshizawa, F, Aizawa, S, Akanuma, Y, Sonenberg, N, Yazaki, Y, Kadowaki, T
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis 1996
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC231302/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8649419/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.16.6.3074
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