ApoE2-associated hypertriglyceridemia is ameliorated by increased levels of apoA-V but unaffected by apoC-III deficiency

Apolipoprotein E2 (apoE2)-associated hyperlipidemia is characterized by a disturbed clearance of apoE2-enriched VLDL remnants. Because excess apoE2 inhibits LPL-mediated triglyceride (TG) hydrolysis in vitro, we investigated whether direct or indirect stimulation of LPL activity in vivo reduces the...

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Bibliografische gegevens
Hoofdauteurs: Gerritsen, Gery, van der Hoogt, Caroline C., Schaap, Frank G., Voshol, Peter J., Kypreos, Kyriakos E., Maeda, Nobuyo, Groen, Albert K., Havekes, Louis M., Rensen, Patrick C. N., van Dijk, Ko Willems
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2008
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2311447/
https://ncbi.nlm.nih.gov/pubmed/18263930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M800009-JLR200
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