Artificial miRNAs mitigate shRNA-mediated toxicity in the brain: Implications for the therapeutic development of RNAi

Huntington's disease (HD) is a fatal, dominant neurodegenerative disease caused by a polyglutamine repeat expansion in exon 1 of the HD gene, which encodes the huntingtin protein. We and others have shown that RNAi is a candidate therapy for HD because expression of inhibitory RNAs targeting mu...

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Bibliografische gegevens
Hoofdauteurs: McBride, Jodi L., Boudreau, Ryan L., Harper, Scott Q., Staber, Patrick D., Monteys, Alex Mas, Martins, Inâs, Gilmore, Brian L., Burstein, Haim, Peluso, Richard W., Polisky, Barry, Carter, Barrie J., Davidson, Beverly L.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2008
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2311380/
https://ncbi.nlm.nih.gov/pubmed/18398004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0801775105
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