Artificial miRNAs mitigate shRNA-mediated toxicity in the brain: Implications for the therapeutic development of RNAi

Huntington's disease (HD) is a fatal, dominant neurodegenerative disease caused by a polyglutamine repeat expansion in exon 1 of the HD gene, which encodes the huntingtin protein. We and others have shown that RNAi is a candidate therapy for HD because expression of inhibitory RNAs targeting mu...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: McBride, Jodi L., Boudreau, Ryan L., Harper, Scott Q., Staber, Patrick D., Monteys, Alex Mas, Martins, Inâs, Gilmore, Brian L., Burstein, Haim, Peluso, Richard W., Polisky, Barry, Carter, Barrie J., Davidson, Beverly L.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2008
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2311380/
https://ncbi.nlm.nih.gov/pubmed/18398004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0801775105
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