Artificial miRNAs mitigate shRNA-mediated toxicity in the brain: Implications for the therapeutic development of RNAi

Huntington's disease (HD) is a fatal, dominant neurodegenerative disease caused by a polyglutamine repeat expansion in exon 1 of the HD gene, which encodes the huntingtin protein. We and others have shown that RNAi is a candidate therapy for HD because expression of inhibitory RNAs targeting mu...

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Detalhes bibliográficos
Main Authors: McBride, Jodi L., Boudreau, Ryan L., Harper, Scott Q., Staber, Patrick D., Monteys, Alex Mas, Martins, Inâs, Gilmore, Brian L., Burstein, Haim, Peluso, Richard W., Polisky, Barry, Carter, Barrie J., Davidson, Beverly L.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2311380/
https://ncbi.nlm.nih.gov/pubmed/18398004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0801775105
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