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Ku86 defines the genetic defect and restores X-ray resistance and V(D)J recombination to complementation group 5 hamster cell mutants.

X-ray-sensitive hamster cells in complementation groups 4, 5, 6, and 7 are impaired for both double-strand break repair and V(D)J recombination. Here we show that in two mutant cell lines (XR-V15B and XR-V9B) from group 5, the genetic defects are in the gene encoding the 86-kDa subunit of the Ku aut...

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Udgivet i:Mol Cell Biol
Principais autores: Errami, A, Smider, V, Rathmell, W K, He, D M, Hendrickson, E A, Zdzienicka, M Z, Chu, G
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 1996
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC231136/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8657125/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.16.4.1519
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