A point mutation in the extracellular domain activates LET-23, the Caenorhabditis elegans epidermal growth factor receptor homolog.

The let-23 gene encodes a Caenorhabditis elegans homolog of the epidermal growth factor receptor (EGFR) necessary for vulval development. We have characterized a mutation of let-23 that activates the receptor and downstream signal transduction, leading to excess vulval differentiation. This mutation...

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Detalhes bibliográficos
Main Authors: Katz, W S, Lesa, G M, Yannoukakos, D, Clandinin, T R, Schlessinger, J, Sternberg, P W
Formato: Artigo
Idioma:Inglês
Publicado em: 1996
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC231031/
https://ncbi.nlm.nih.gov/pubmed/8552080
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