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Constitutive activation of S6 kinase by deletion of amino-terminal autoinhibitory and rapamycin sensitivity domains.

The mitogen response of p70/p85 S6 kinase (S6K) parallels that of mitogen-activated protein kinases (MAPK). However, S6K lies on a discrete signaling pathway from MAPK, since the immunosuppressant drug rapamycin inactivates S6K without affecting the MAPK cascade. Phosphatidylinositol 3-kinase operat...

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Udgivet i:Mol Cell Biol
Principais autores: Mahalingam, M, Templeton, D J
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 1996
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC231016/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8524322/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.16.1.405
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