Dose-response resistance to HIV-1/MuLV pseudotype virus ex vivo in a hairpin ribozyme transgenic mouse model

We have investigated the efficacy of a hairpin ribozyme targeting the 5′ leader sequence of HIV-1 RNA in a transgenic model system. Primary spleen cells derived from transgenic or control mice were infected with HIV-1/MuLV pseudotype virus. A significantly reduced susceptibility to infection in ribo...

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書誌詳細
主要な著者: Andäng, Michael, Hinkula, Jorma, Hotchkiss, Graham, Larsson, Sten, Britton, Sven, Wong-Staal, Flossie, Wahren, Britta, Ährlund-Richter, Lars
フォーマット: Artigo
言語:Inglês
出版事項: The National Academy of Sciences 1999
主題:
Biological Sciences
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC23081/
https://ncbi.nlm.nih.gov/pubmed/10535994
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