Dose-response resistance to HIV-1/MuLV pseudotype virus ex vivo in a hairpin ribozyme transgenic mouse model

We have investigated the efficacy of a hairpin ribozyme targeting the 5′ leader sequence of HIV-1 RNA in a transgenic model system. Primary spleen cells derived from transgenic or control mice were infected with HIV-1/MuLV pseudotype virus. A significantly reduced susceptibility to infection in ribo...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Andäng, Michael, Hinkula, Jorma, Hotchkiss, Graham, Larsson, Sten, Britton, Sven, Wong-Staal, Flossie, Wahren, Britta, Ährlund-Richter, Lars
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1999
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC23081/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10535994/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.22.12749
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