A truncated herpes simplex virus thymidine kinase phosphorylates thymidine and nucleoside analogs and does not cause sterility in transgenic mice.

Dividing eukaryotic cells expressing the herpes simplex virus type 1 thymidine kinase (TK) gene are sensitive to the cytotoxic effect of nucleoside analogs such as acyclovir or ganciclovir (GCV). Transgenic mice with cell-targeted expression of this conditional toxin have been used to create animals...

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Pubblicato in:	Mol Cell Biol
Autori principali:	Salomon, B, Maury, S, Loubière, L, Caruso, M, Onclercq, R, Klatzmann, D
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis 1995
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC230780/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7565681/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.15.10.5322
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