A proline-rich sequence unique to MEK1 and MEK2 is required for raf binding and regulates MEK function.

Mammalian MEK1 and MEK2 contain a proline-rich (PR) sequence that is absent both from the yeast homologs Ste7 and Byr1 and from a recently cloned activator of the JNK/stress-activated protein kinases, SEK1/MKK4. Since this PR sequence occurs in MEKs that are regulated by Raf family enzymes but is mi...

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Bibliographic Details

Published in:	Mol Cell Biol
Main Authors:	Catling, A D, Schaeffer, H J, Reuter, C W, Reddy, G R, Weber, M J
Format:	Artigo
Language:	Inglês
Published:	Taylor & Francis 1995
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC230769/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7565670/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.15.10.5214
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