The monomer-binding orphan receptor Rev-Erb represses transcription as a dimer on a novel direct repeat.

Rev-Erb is an orphan nuclear receptor which binds as a monomer to the thyroid/retinoic acid receptor half-site AGGTCA flanked 5' by an A/T-rich sequence, referred to here as a Rev monomer site. Fusion of Rev-Erb to the DNA binding domain of yeast GAL4 strongly repressed basal transcription of a...

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Bibliographic Details
Main Authors: Harding, H P, Lazar, M A
Format: Artigo
Language:Inglês
Published: 1995
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC230723/
https://ncbi.nlm.nih.gov/pubmed/7651396
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