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The monomer-binding orphan receptor Rev-Erb represses transcription as a dimer on a novel direct repeat.

Rev-Erb is an orphan nuclear receptor which binds as a monomer to the thyroid/retinoic acid receptor half-site AGGTCA flanked 5' by an A/T-rich sequence, referred to here as a Rev monomer site. Fusion of Rev-Erb to the DNA binding domain of yeast GAL4 strongly repressed basal transcription of a GAL4...

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Publicado en:Mol Cell Biol
Principais autores: Harding, H P, Lazar, M A
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis 1995
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC230723/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7651396/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.15.9.4791
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