Insulin receptor substrate 1 rescues insulin action in CHO cells expressing mutant insulin receptors that lack a juxtamembrane NPXY motif.

Insulin signals are mediated through tyrosine phosphorylation of specific proteins such as insulin receptor substrate 1 (IRS-1) and Shc by the activated insulin receptor (IR). Phosphorylation of both proteins is nearly abolished by an alanine substitution at Tyr-960 (A960) in the beta-subunit of the...

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Pubblicato in:	Mol Cell Biol
Autori principali:	Chen, D, Van Horn, D J, White, M F, Backer, J M
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis 1995
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC230714/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7651388/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.15.9.4711
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