Cyclin A-associated kinase activity is rate limiting for entrance into S phase and is negatively regulated in G1 by p27Kip1.

We have created fibroblast cell lines that express cyclin A under the control of a tetracycline-repressible promoter. When stimulated to reenter the cell cycle after serum withdrawal, these cells were advanced prematurely into S phase by induction of cyclin A. In an asynchronous population, inductio...

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Veröffentlicht in:	Mol Cell Biol
Hauptverfasser:	Resnitzky, D, Hengst, L, Reed, S I
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis 1995
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC230674/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7623829/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.15.8.4347
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