Cyclin A-associated kinase activity is rate limiting for entrance into S phase and is negatively regulated in G1 by p27Kip1.
We have created fibroblast cell lines that express cyclin A under the control of a tetracycline-repressible promoter. When stimulated to reenter the cell cycle after serum withdrawal, these cells were advanced prematurely into S phase by induction of cyclin A. In an asynchronous population, inductio...
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| Udgivet i: | Mol Cell Biol |
|---|---|
| Principais autores: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Taylor & Francis
1995
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC230674/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7623829/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.15.8.4347 |
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