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Inhibition of cellular proliferation by the Wilms' tumor suppressor WT1 is associated with suppression of insulin-like growth factor I receptor gene expression.

We have investigated the regulation of the insulin-like growth factor I receptor (IGF-I-R) gene promoter by the Wilms' tumor suppressor WT1 in intact cells. The levels of endogenous IGF-I-R mRNA and the activity of IGF-I-R gene promoter fragments in luciferase reporter constructs were found to be si...

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Udgivet i:Mol Cell Biol
Principais autores: Werner, H, Shen-Orr, Z, Rauscher, F J, Morris, J F, Roberts, C T, LeRoith, D
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 1995
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC230588/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7791758/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.15.7.3516
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