Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators.

To gain insight into the function of peroxisome proliferator-activated receptor (PPAR) isoforms in rodents, we disrupted the ligand-binding domain of the alpha isoform of mouse PPAR (mPPAR alpha) by homologous recombination. Mice homozygous for the mutation lack expression of mPPAR alpha protein and...

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Detalhes bibliográficos
Main Authors: Lee, S S, Pineau, T, Drago, J, Lee, E J, Owens, J W, Kroetz, D L, Fernandez-Salguero, P M, Westphal, H, Gonzalez, F J
Formato: Artigo
Idioma:Inglês
Publicado em: 1995
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC230532/
https://ncbi.nlm.nih.gov/pubmed/7539101
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