The ligand-binding domains of the thyroid hormone/retinoid receptor gene subfamily function in vivo to mediate heterodimerization, gene silencing, and transactivation.

The ligand-binding domains (LBDs) of the thyroid/retinoid receptor gene subfamily contain a series of heptad motifs important for dimeric interactions. This subfamily includes thyroid hormone receptors (T3Rs), all-trans retinoic acid (RA) receptors (RARs), 9-cis RA receptors (RARs and retinoid X rec...

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Vydáno v:	Mol Cell Biol
Hlavní autoři:	Qi, J S, Desai-Yajnik, V, Greene, M E, Raaka, B M, Samuels, H H
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Taylor & Francis 1995
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC230406/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7862171/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.15.3.1817
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The ligand-binding domains of the thyroid hormone/retinoid receptor gene subfamily function in vivo to mediate heterodimerization, gene silencing, and transactivation.

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