The ligand-binding domains of the thyroid hormone/retinoid receptor gene subfamily function in vivo to mediate heterodimerization, gene silencing, and transactivation.

Gelijkaardige items

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  door: Desai-Yajnik, V, et al.
  Gepubliceerd in: (1995)
• A shift in the ligand responsiveness of thyroid hormone receptor alpha induced by heterodimerization with retinoid X receptor alpha.
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• Functional evidence for ligand-dependent dissociation of thyroid hormone and retinoic acid receptors from an inhibitory cellular factor.
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• Constitutive activation of gene expression by thyroid hormone receptor results from reversal of p53-mediated repression.
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