c-jun inhibits insulin control element-mediated transcription by affecting the transactivation potential of the E2A gene products.

Pancreatic beta-cell-type-specific transcription of the insulin gene is principally controlled by trans-acting factors which influence insulin control element (ICE)-mediated expression. The ICE activator is composed, in part, of the basic helix-loop-helix proteins E12, E47, and E2-5 encoded by the E...

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Bibliographic Details
Main Authors: Robinson, G L, Henderson, E, Massari, M E, Murre, C, Stein, R
Format: Artigo
Language:Inglês
Published: 1995
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC230364/
https://ncbi.nlm.nih.gov/pubmed/7862133
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