Receptor-associated constitutive protein tyrosine phosphatase activity controls the kinase function of JAK1

Exposure of cells to protein tyrosine phosphatase (PTP) inhibitors causes an increase in the phosphotyrosine content of many cellular proteins. However, the level at which the primary signaling event is affected is still unclear. We show that Jaks are activated by tyrosine phosphorylation in cells t...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Haque, S. Jaharul, Wu, Qian, Kammer, Winfried, Friedrich, Karlheinz, Smith, Jonathan M., Kerr, Ian M., Stark, George R., Williams, Bryan R. G.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1997
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC23014/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9238016/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.16.8563
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