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In vitro selection of a 7-methyl-guanosine binding RNA that inhibits translation of capped mRNA molecules

Using systematic evolution of ligands by exponential enrichment (SELEX), an RNA molecule was isolated that displays a 1,000-fold higher affinity for guanosine residues that carry an N-7 methyl group than for nonmethylated guanosine residues. The methylated guanosine residue closely resembles the 5′...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Haller, Aurelia A., Sarnow, Peter
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1997
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22984/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9238009/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.16.8521
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