In vitro selection of a 7-methyl-guanosine binding RNA that inhibits translation of capped mRNA molecules
Using systematic evolution of ligands by exponential enrichment (SELEX), an RNA molecule was isolated that displays a 1,000-fold higher affinity for guanosine residues that carry an N-7 methyl group than for nonmethylated guanosine residues. The methylated guanosine residue closely resembles the 5′...
Shranjeno v:
| izdano v: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
1997
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22984/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9238009/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.16.8521 |
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