DOT1L/KMT4 Recruitment and H3K79 Methylation Are Ubiquitously Coupled with Gene Transcription in Mammalian Cells

The histone H3 lysine 79 methyltransferase DOT1L/KMT4 can promote an oncogenic pattern of gene expression through binding with several MLL fusion partners found in acute leukemia. However, the normal function of DOT1L in mammalian gene regulation is poorly understood. Here we report that DOT1L recru...

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Main Authors: Steger, David J., Lefterova, Martina I., Ying, Lei, Stonestrom, Aaron J., Schupp, Michael, Zhuo, David, Vakoc, Adam L., Kim, Ja-Eun, Chen, Junjie, Lazar, Mitchell A., Blobel, Gerd A., Vakoc, Christopher R.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2008
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2293113/
https://ncbi.nlm.nih.gov/pubmed/18285465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.02076-07
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