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Physiological Significance of Reactive Cysteine Residues of Keap1 in Determining Nrf2 Activity
Keap1 and Cul3 constitute a unique ubiquitin E3 ligase that degrades Nrf2, a key activator of cytoprotective genes. Upon exposure to oxidants/electrophiles, the enzymatic activity of this ligase complex is inhibited and the complex fails to degrade Nrf2, resulting in the transcriptional activation o...
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| 主要な著者: | , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Microbiology (ASM)
2008
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2293100/ https://ncbi.nlm.nih.gov/pubmed/18268004 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01704-07 |
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