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Activated Kras, but Not Hras or Nras, May Initiate Tumors of Endodermal Origin via Stem Cell Expansion

The three closely related human Ras genes, Hras, Nras, and Kras, are all widely expressed, engage a common set of downstream effectors, and can each exhibit oncogenic activity. However, the vast majority of activating Ras mutations in human tumors involve Kras. Moreover, Kras mutations are most freq...

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Hlavní autoři: Quinlan, Margaret P., Quatela, Steven E., Philips, Mark R., Settleman, Jeffrey
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2293097/
https://ncbi.nlm.nih.gov/pubmed/18268007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01661-07
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