Presenilin 1 Interacts with Acetylcholinesterase and Alters Its Enzymatic Activity and Glycosylation

Presenilin 1 (PS1) plays a critical role in the γ-secretase processing of the amyloid precursor protein to generate the β-amyloid peptide, which accumulates in plaques in the pathogenesis of Alzheimer's disease (AD). Mutations in PS1 cause early onset AD, and proteins that interact with PS1 are...

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Main Authors: Silveyra, María-Ximena, Evin, Geneviève, Montenegro, María-Fernanda, Vidal, Cecilio J., Martínez, Salvador, Culvenor, Janetta G., Sáez-Valero, Javier
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2008
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2293086/
https://ncbi.nlm.nih.gov/pubmed/18299393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.02065-07
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