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Larger Vancomycin Doses (at Least Four Grams per Day) Are Associated with an Increased Incidence of Nephrotoxicity

Recent guidelines recommend vancomycin trough concentrations between 15 and 20 mg/liter. In response, some clinicians increased vancomycin dosing to ≥4 g/day. Scant data are available regarding toxicities associated with higher vancomycin doses. The purpose of this study was to examine vancomycin-as...

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Autors principals: Lodise, Thomas P., Lomaestro, Ben, Graves, Jeffrey, Drusano, G. L.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2292536/
https://ncbi.nlm.nih.gov/pubmed/18227177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01602-07
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