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Characterization of a Novel Human Immunodeficiency Virus Type 1 Protease Inhibitor, A-790742

A-790742 is a potent human immunodeficiency virus type 1 (HIV-1) protease inhibitor, with 50% effective concentrations ranging from 2 to 7 nM against wild-type HIV-1. The activity of this compound is lowered by approximately sevenfold in the presence of 50% human serum. A-790742 maintained potent an...

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Autori principali: Dekhtyar, Tatyana, Ng, Teresa I., Lu, Liangjun, Masse, Sherie, DeGoey, David A., Flosi, William J., Grampovnik, David J., Klein, Larry L., Kempf, Dale J., Molla, Akhteruzzaman
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2292532/
https://ncbi.nlm.nih.gov/pubmed/18212102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01132-07
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