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Spontaneous Deletion of the Methicillin Resistance Determinant, mecA, Partially Compensates for the Fitness Cost Associated with High-Level Vancomycin Resistance in Staphylococcus aureus

Treatment of infections caused by Staphylococcus aureus is often confounded by the bacterium's ability to develop resistance to chemotherapeutic agents. Methicillin-resistant S. aureus (MRSA) arises through the acquisition of staphylococcal chromosomal cassette mec (SCCmec), a genomic island co...

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Bibliografiske detaljer
Main Authors: Noto, Michael J., Fox, Paige M., Archer, Gordon L.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2292509/
https://ncbi.nlm.nih.gov/pubmed/18212094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01164-07
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