Convergent In Vivo and In Vitro Selection of Ceftazidime Resistance Mutations at Position 167 of CTX-M-3 β-Lactamase in Hypermutable Escherichia coli Strains

We report on a novel CTX-M extended-spectrum β-lactamase (ESBL), designated CTX-M-42, with enhanced activity toward ceftazidime. CTX-M-42 was identified in a hypermutable Escherichia coli nosocomial isolate (isolate Irk2320) and is a Pro167Thr amino acid substitution variant of CTX-M-3. By molecular...

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Hlavní autoři: Stepanova, Marina N., Pimkin, Maxim, Nikulin, Anatoly A., Kozyreva, Varvara K., Agapova, Elena D., Edelstein, Mikhail V.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2008
Témata:
Mechanisms of Resistance
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2292507/
https://ncbi.nlm.nih.gov/pubmed/18212109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01060-07
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