A Novel Mutant Cardiac Troponin C Disrupts Molecular Motions Critical for Calcium Binding Affinity and Cardiomyocyte Contractility

Troponin C (TnC) belongs to the superfamily of EF-hand (helix–loop–helix) Ca(2+)-binding proteins and is an essential component of the regulatory thin filament complex. In a patient diagnosed with idiopathic dilated cardiomyopathy, we identified two novel missense mutations localized in the regulato...

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Bibliographische Detailangaben
Hauptverfasser: Lim, Chee Chew, Yang, Haijun, Yang, Mingfeng, Wang, Chien-Kao, Shi, Jianru, Berg, Eric A., Pimentel, David R., Gwathmey, Judith K., Hajjar, Roger J., Helmes, Michiel, Costello, Catherine E., Huo, Shuanghong, Liao, Ronglih
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Biophysical Society 2008
Schlagworte:
Muscle and Contractility
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2292379/
https://ncbi.nlm.nih.gov/pubmed/18212018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.112896
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