3α-Hydroxysteroid Dehydrogenase Type III Deficiency: A Novel Mechanism for Hirsutism

Context: Dihydrotestosterone (DHT), the primary active androgen in peripheral target tissues, is metabolized by 3α-hydroxysteroid dehydrogenase type III (3α-HSD), encoded by the AKR1C2 gene, forming 5α-androstane-3α,17β-diol (3α-diol). 3α-HSD may play a role in the pathogenesis of hirsutism. Objecti...

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Detalhes bibliográficos
Main Authors: Steiner, Anne Z., Chang, Lilly, Ji, Qing, Ookhtens, Murad, Stolz, Andrew, Paulson, Richard J., Stanczyk, Frank Z.
Formato: Artigo
Idioma:Inglês
Publicado em: The Endocrine Society 2008
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2291485/
https://ncbi.nlm.nih.gov/pubmed/18252781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2007-2708
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