Pharmacokinetic modelling of interleukin-1 receptor antagonist in plasma and cerebrospinal fluid of patients following subarachnoid haemorrhage

AIM: The naturally occurring interlukin-1 receptor antagonist (IL-1RA) markedly protects rodents against ischaemic, excitotoxic and traumatic brain injury, suggesting it may be of therapeutic value. The aim was to determine the pharmacokinetics of IL-1RA in cerebrospinal fluid (CSF) of patients, to...

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Bibliografiske detaljer
Main Authors: Gueorguieva, Ivelina, Clark, Simon R, McMahon, Catherine J, Scarth, Sylvia, Rothwell, Nancy J, Tyrell, Pippa J, Hopkins, Stephen J, Rowland, Malcolm
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Science Inc 2008
Fag:
Pharmacokinetics and Pharmacodynamics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2291249/
https://ncbi.nlm.nih.gov/pubmed/17875190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2007.03026.x
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