Three metal ions at the active site of the Tetrahymena group I ribozyme

Metal ions are critical for catalysis by many RNA and protein enzymes. To understand how these enzymes use metal ions for catalysis, it is crucial to determine how many metal ions are positioned at the active site. We report here an approach, combining atomic mutagenesis with quantitative determinat...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Shan, Shu-ou, Yoshida, Aiichiro, Sun, Sengen, Piccirilli, Joseph A., Herschlag, Daniel
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1999
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22911/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10535916/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.22.12299
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