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A two-step nucleotide-flipping mechanism enables kinetic discrimination of DNA lesions by AGT
O(6)-alkylguanine-DNA alkyltransferase (AGT) repairs damage to the human genome by flipping guanine and thymine bases into its active site for irreversible transfer of alkyl lesions to Cys-145, but how the protein identifies its targets has remained unknown. Understanding molecular recognition in th...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2290773/ https://ncbi.nlm.nih.gov/pubmed/18353991 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0708058105 |
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