Age-dependent synapse withdrawal at axotomised neuromuscular junctions in Wld(s) mutant and Ube4b/Nmnat transgenic mice

Axons in Wld(S) mutant mice are protected from Wallerian degeneration by overexpression of a chimeric Ube4b/Nmnat (Wld) gene. Expression of Wld protein was independent of age in these mice. However we identified two distinct neuromuscular synaptic responses to axotomy. In young adult Wld(s) mice, ax...

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Detalhes bibliográficos
Main Authors: Gillingwater, Thomas H, Thomson, Derek, Mack, Till G A, Soffin, Ellen M, Mattison, Richard J, Coleman, Michael P, Ribchester, Richard R
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2002
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2290540/
https://ncbi.nlm.nih.gov/pubmed/12231635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2002.022343
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