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Nitric oxide inhibits neuroendocrine Ca(V)1 L-channel gating via cGMP-dependent protein kinase in cell-attached patches of bovine chromaffin cells

Nitric oxide (NO) regulates the release of catecholamines from the adrenal medulla but the molecular targets of its action are not yet well identified. Here we show that the NO donor sodium nitroprusside (SNP, 200 μM) causes a marked depression of the single Ca(V)1 L-channel activity in cell-attache...

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Detalhes bibliográficos
Main Authors: Carabelli, Valentina, D'Ascenzo, Marcello, Carbone, Emilio, Grassi, Claudio
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2290346/
https://ncbi.nlm.nih.gov/pubmed/12042344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2002.017749
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