When the Genome Plays Dice: Circumvention of the Spindle Assembly Checkpoint and Near-Random Chromosome Segregation in Multipolar Cancer Cell Mitoses

BACKGROUND: Normal cell division is coordinated by a bipolar mitotic spindle, ensuring symmetrical segregation of chromosomes. Cancer cells, however, occasionally divide into three or more directions. Such multipolar mitoses have been proposed to generate genetic diversity and thereby contribute to...

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Main Authors: Gisselsson, David, Håkanson, Ulf, Stoller, Patrick, Marti, Dominik, Jin, Yuesheng, Rosengren, Anders H., Stewénius, Ylva, Kahl, Fredrik, Panagopoulos, Ioannis
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2008
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2289843/
https://ncbi.nlm.nih.gov/pubmed/18392149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0001871
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