Structure of antibody F425-B4e8 in complex with a V3 peptide reveals a new binding mode for HIV-1 neutralization

F425-B4e8 (B4e8) is a monoclonal antibody isolated from a human immunodeficiency virus type 1 (HIV-1)-infected individual that recognizes the V3 variable loop on the gp120 subunit of the viral envelope spike. B4e8 neutralizes a subset of HIV-1 primary isolates from subtypes B, C and D, which places...

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Bibliografiske detaljer
Main Authors: Bell, Christian H., Pantophlet, Ralph, Schiefner, André, Cavacini, Lisa A., Stanfield, Robyn L., Burton, Dennis R., Wilson, Ian A.
Format: Artigo
Sprog:Inglês
Udgivet: 2007
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2289799/
https://ncbi.nlm.nih.gov/pubmed/18068724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2007.11.013
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