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Uncoupled cell cycle without mitosis induced by a protein kinase inhibitor, K-252a
The staurosporine analogues, K-252a and RK-286C, were found to cause DNA re-replication in rat diploid fibroblasts (3Y1) without an intervening mitosis, producing tetraploid cells. Analysis of cells synchronized in early S phase in the presence of K-252a revealed that initiation of the second S phas...
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| Natura: | Artigo |
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| Lingua: | Inglês |
| Pubblicazione: |
The Rockefeller University Press
1991
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| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2289235/ https://ncbi.nlm.nih.gov/pubmed/1955475 |
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