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Enzyme structural plasticity and the emergence of broad-spectrum antibiotic resistance
The emergence of multi-resistant pathogenic bacteria is a worldwide health issue. Recently, clinical variants of a single antibiotic-modifying acetyltransferase, AAC(6′)-Ib—a variant of aminoglycoside 6′-N-acetyltransferase—have been identified that confer extended resistance to most aminoglycosides...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2288771/ https://ncbi.nlm.nih.gov/pubmed/18292754 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2008.9 |
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