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1,2-Dioleoyl-3-Trimethylammonium-Propane (DOTAP)-Formulated, Immune-Stimulatory Vascular Endothelial Growth Factor A Small Interfering RNA (siRNA) Increases Antitumoral Efficacy in Murine Orthotopic Hepatocellular Carcinoma with Liver Fibrosis

Most experimental therapy studies are performed in mice that bear subcutaneous or orthotopic hepatoma but are otherwise healthy and nonfibrotic. The majority of hepatocellular carcinoma (HCC), however, develops in patients suffering from preexisting liver fibrosis. We investigated the efficacy of a...

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Detalhes bibliográficos
Main Authors: Kornek, Miroslaw, Lukacs-Kornek, Veronika, Limmer, Andreas, Raskopf, Esther, Becker, Ursula, Klöckner, Maren, Sauerbruch, Tilman, Schmitz, Volker
Formato: Artigo
Idioma:Inglês
Publicado em: ScholarOne 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2288535/
https://ncbi.nlm.nih.gov/pubmed/18392108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/2008-00003.Kornek
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