1,2-Dioleoyl-3-Trimethylammonium-Propane (DOTAP)-Formulated, Immune-Stimulatory Vascular Endothelial Growth Factor A Small Interfering RNA (siRNA) Increases Antitumoral Efficacy in Murine Orthotopic Hepatocellular Carcinoma with Liver Fibrosis

Most experimental therapy studies are performed in mice that bear subcutaneous or orthotopic hepatoma but are otherwise healthy and nonfibrotic. The majority of hepatocellular carcinoma (HCC), however, develops in patients suffering from preexisting liver fibrosis. We investigated the efficacy of a...

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Autores principales: Kornek, Miroslaw, Lukacs-Kornek, Veronika, Limmer, Andreas, Raskopf, Esther, Becker, Ursula, Klöckner, Maren, Sauerbruch, Tilman, Schmitz, Volker
Formato: Artigo
Lenguaje:Inglês
Publicado: ScholarOne 2008
Materias:
Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2288535/
https://ncbi.nlm.nih.gov/pubmed/18392108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/2008-00003.Kornek
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