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Simulation of the activation of α-chymotrypsin: Analysis of the pathway and role of the propeptide
α-Chymotrypsin undergoes a reversible conformational change from an inactive chymotrypsinogen-like structure at high pH to an active conformation at neutral pH. In order to gain insight into this process on a structural level, we applied molecular dynamics and targeted molecular dynamics simulations...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Cold Spring Harbor Laboratory Press
2004
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2287318/ https://ncbi.nlm.nih.gov/pubmed/15557259 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.04825004 |
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