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Evolutionarily conserved regions and hydrophobic contacts at the superfamily level: The case of the fold-type I, pyridoxal-5′-phosphate-dependent enzymes

The wealth of biological information provided by structural and genomic projects opens new prospects of understanding life and evolution at the molecular level. In this work, it is shown how computational approaches can be exploited to pinpoint protein structural features that remain invariant upon...

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Hlavní autoři: Paiardini, Alessandro, Bossa, Francesco, Pascarella, Stefano
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2004
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2286575/
https://ncbi.nlm.nih.gov/pubmed/15498941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.04938104
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