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In silico protein design by combinatorial assembly of protein building blocks
Utilizing concepts of protein building blocks, we propose a de novo computational algorithm that is similar to combinatorial shuffling experiments. Our goal is to engineer new naturally occurring folds with low homology to existing proteins. A selected protein is first partitioned into its building...
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| Päätekijät: | , , , |
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| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Cold Spring Harbor Laboratory Press
2004
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2286547/ https://ncbi.nlm.nih.gov/pubmed/15388863 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.04774004 |
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