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In silico protein design by combinatorial assembly of protein building blocks

Utilizing concepts of protein building blocks, we propose a de novo computational algorithm that is similar to combinatorial shuffling experiments. Our goal is to engineer new naturally occurring folds with low homology to existing proteins. A selected protein is first partitioned into its building...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Tsai, Hui-Hsu (Gavin), Tsai, Chung-Jung, Ma, Buyong, Nussinov, Ruth
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Cold Spring Harbor Laboratory Press 2004
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC2286547/
https://ncbi.nlm.nih.gov/pubmed/15388863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.04774004
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