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New Inhibitors of Scrapie-Associated Prion Protein Formation in a Library of 2,000 Drugs and Natural Products

Transmissible spongiform encephalopathies (TSEs) are fatal, untreatable neurodegenerative diseases associated with the accumulation of a disease-specific form of prion protein (PrP) in the brain. One approach to TSE therapeutics is the inhibition of PrP accumulation. Indeed, many inhibitors of the a...

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Udgivet i:J Virol
Principais autores: Kocisko, David A., Baron, Gerald S., Rubenstein, Richard, Chen, Jiancao, Kuizon, Salomon, Caughey, Byron
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2003
Fag:
Vaccines and Antiviral Agents
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC228499/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12970413/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.77.19.10288-10294.2003
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